ea0021p156 | Diabetes and metabolism | SFEBES2009
Zhang Lei
, Steadman Robert
, de Lloyd Anna
, Ham Jack
, Rees Aled
, Ludgate Marian
Obesity (excess adipose tissue generated by hypertrophy and hyperplasia) predisposes to poor health. Adipogenesis (hyperplasia) involves the differentiation of adherent preadipocytes into non-adherent adipocytes and is accompanied by alterations to the extracellular matrix of which hyaluronan (HA) is a component. Used in vitro to promote lineage specific differentiation, little is known of HAs role in adipogenesis. We hypothesise that HA modifications must occur d...